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SynVivo
3D Tissue and Organ-on-Chip Models
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Publications

NX210c drug candidate peptide strengthens mouse and human blood-brain barriers

PublicationsBy Grace McGrewSeptember 27, 2024

Authors: Chris Greene, Nicolas Rebergue, Gwen Fewell, Damir Janigro, Yann Godfrin, Matthew Campbell & Sighild Lemarchant  Source: Fluids and Barriers of the CNS Published online: September 27, 2024. Synopsis: Background: Alterations of blood-brain barrier (BBB) and blood-spinal…

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Distinct functional neutrophil phenotypes in sepsis patients correlate with disease severity

PublicationsBy Grace McGrewMarch 7, 2024

Authors: Qingliang Yang, Jordan C. Langston, Roman Prosniak,Samantha Pettigrew, Huaqing Zhao, Edwin Perez, Hannah Edelmann, Nadia Mansoor, Carmen Merali, Salim Merali, Nathaniel Marchetti, Balabhaskar Prabhakarpandian, Mohammad F. Kiani, Laurie E.…

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A biomimetic chip to assess subcutaneous bioavailability of monoclonal antibodies in humans

PublicationsBy rdtOctober 9, 2023

Authors: Vineeth Chandran Suja, Qin M Qi, Kevin Halloran, Jifeng Zhang, Suyog Shaha, Supriya Prakash, Ninad Kumbhojkar, Antoine Deslandes, Sylvain Huille, Yatin R Gokarn, Samir Mitragotri Source: PNAS Nexus Published…

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Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies

PublicationsBy Gwen FewellJune 14, 2022

Authors: Jez Huang, Ying Betty Li, Claudie Charlebois, Tina Nguyen, Ziying Liu, Darin Bloemberg, Ahmed Zafer, Ewa Baumann, Caroline Sodja, Sonia Leclerc, Gwen Fewell, Qing Liu, Balabhaskar Prabhakarpandian, Scott McComb,…

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3D Tissue and Organ-on-Chip Models

PublicationsBy Gwen FewellOctober 20, 2021

Authors: SynVivo Synopsis: SynVivo® is a cell-based microfluidic platform that provides a morphologically and physiologically realistic microenvironment allowing real-time study of cellular behavior, drug delivery, and drug discovery. SynVivo’s 3D…

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A Microfluidic Platform for Cavitation-Enhanced Drug Delivery

PublicationsBy Gwen FewellJune 9, 2021

Authors: Giulia Grisanti, Davide Caprini, Giorgia Sinibaldi, Chiara Scognamiglio, Giulia Silvani , Giovanna Peruzzi, and Carlo Massimo Casciola Source: MDPI Open Access Journals Micromachines Published online: June 3, 2021. Synopsis:…

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A 3-dimensional microfluidic platform for modeling human extravillous trophoblast invasion and toxicological screening

PublicationsBy Gwen FewellJune 9, 2021

Authors: Yong Pu, Jeremy Gingrich and Almudena Veiga-Lopez Source: pubs.rsc.org Lab on a Chip Received: October 7, 2020. Accepted: November 2, 2020. Published online: November 9, 2020. Synopsis: Placental trophoblast…

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small journal

Cellular Interactions of Liposomes and PISA Nanoparticles during Human Blood Flow in a Microvascular Network

PublicationsBy Gwen FewellJune 25, 2020

Authors: Mai N. Vu, Hannah G. Kelly, Adam K. Wheatley, Scott Peng, Emily H. Pilkington, Nicholas A. Veldhuis, Thomas P. Davis, Stephen J. Kent, and Nghia P. Truong Source: onlinelibrary.wiley.com…

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shock2020

Experimental Approaches to Evaluate Leukocyte-Endothelial Cell Interactions in Sepsis and Inflammation

PublicationsBy Gwen FewellFebruary 19, 2020

Authors: Kilpatrick, Laurie E.; Kiani, Mohammad F. SHOCK: May 2020 – Volume 53 – Issue 5 – p 585-595 doi: 10.1097/SHK.0000000000001407 Synopsis: Sepsis is a life-threatening syndrome of organ dysfunction…

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FASEB

Neutrophil‐endothelial interactions of murine cells is not a good predictor of their interactions in human cells

PublicationsBy Gwen FewellDecember 23, 2019

Authors: Fariborz Soroush, Yuan Tang, Omar Mustafa, Shuang Sun, Qingliang Yang, Laurie E. Kilpatrick, Mohammad F. Kiani Synopsis: All drugs recently developed in rodent models to treat inflammatory disease have…

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small journal

Reversible Cavitation-Induced Junctional Opening in an Artificial Endothelial Layer

PublicationsBy Gwen FewellNovember 25, 2019

Authors: Giulia Silvani, Chiara Scognamiglio, Davide Caprini, Luca Marino, Mauro Chinappi, Giorgia Sinibaldi, Giovanna Peruzzi, Mohammad F. Kiani, and Carlo M. Casciola Source: onlinelibrary.wiley.com Advance Science News, Small Journal Received:…

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OSA journal

Co-Cultured Microfluidic Model Of The Airway Optimized For Microscopy And Micro-Optical Coherence Tomography Imaging

PublicationsBy Gwen FewellNovember 2, 2019

Authors: Zhongyu Liu, Stephen Mackay, Dylan M. Gordon, Justin D. Anderson, Dustin W. Haithcock, Charles J. Garson, Guillermo J. Tearney, George M. Solomon, Kapil Pant, Balabhaskar Prabhakarpandian, Steven M. Rowe,…

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bioengineering translational medicine

Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow

PublicationsBy Grace McGrewSeptember 20, 2019

Authors: Maxsymilian Nowak, Tyler Brown, Adam Graham, Matthew Helgeson and Samir Mitragotri Source: Bioengineering and Translational Medicine Published online: September 20, 2019. Synopsis: Nanoparticle-based therapeutic formulations are being increasingly explored for…

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journal of controlled release

Shape Effect In Active Targeting Of Nanoparticles To Inflamed Cerebral Endothelium Under Static And Flow Conditions

PublicationsBy Gwen FewellSeptember 10, 2019

Authors: A. Da Silva-Candal, T. Brown, V. Krishnan, I. Lopez-Loureiro, P. Ávila-Gómez, A.Pusuluri, A. Pérez-Díaz, C. Correa-Paz, P. Hervella, J. Castillo, S. Mitragotri, F. Campos Source: sciencedirect.com Journal of Controlled…

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applied nano materials journal

Rapid Assessment of Nanoparticle Extravasation in a Microfluidic Tumor Model

PublicationsBy Gwen FewellMarch 29, 2019

Authors: Mai N. Vu, Pradeep Rajasekhar, Daniel P. Poole, Song Yang Khor, Nghia P. Truong, Cameron J. Nowell, John F. Quinn, Michael Whittaker, Nicholas A. Veldhuis, and Thomas P. Davis…

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international journal of molecular sciences

The Role of Tyrosine Phosphorylation of Protein Kinase C Delta in Infection and Inflammation

PublicationsBy Gwen FewellMarch 26, 2019

Authors: Qingliang Yang, Jordan C. Langston, Yuan Tang, Mohammad F. Kiani, and Laurie E. Kilpatrick Source: ncbi.nlm.nih.gov Int J Mol Sci. 2019 Mar; 20(6): 1498. Published online 2019 Mar 26.…

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bioengineering translational medicine

A Microfluidic Model Of Human Brain (uHuB) For Assessment of Blood Brain Barrier

PublicationsBy Gwen FewellDecember 11, 2018

Authors: Tyler D. Brown, Maksymilian Nowak, Alexandra V. Bayles, Balabhaskar Prabhakarpandian, Pankaj Karande, Joerg Lahann, Matthew E. Helgeson, Samir Mitragotri Source: onlinelibrary.wiley.com WILEY AIChE, Bioengineering and Translational Medicine Received: 7…

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journal of neuroinflammation

Protein Kinase C-Delta Inhibition Protects Blood-Brain Barrier From Sepsis-Induced Vascular Damage

PublicationsBy Gwen FewellNovember 6, 2018

Authors: Yuan Tang, Fariborz Soroush, Shuang Sun, Elisabetta Liverani, Jordan C. Langston, Qingliang Yang, Laurie E. Kilpatrick, and Mohammad F. Kiani Source: ncbi.nlm.nih.gov Tang et al. Journal of Neuroinflammation (2018)…

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Characterization of human fetal brain endothelial cells reveals barrier properties suitable for in vitro modeling of the BBB with syngenic co-cultures

PublicationsBy Gwen FewellOctober 20, 2018

Authors: Allison M Andrews, Evan M Lutton, Lee A Cannella, Nancy Reichenbach, Roshanak Razmpour, Matthew J Seasock, Steven J Kaspin, Steven F Merkel, Dianne Langford, Yuri Persidsky and Servio H…

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small journal

Elucidating the Influences of Size, Surface Chemistry, and Dynamic Flow on Cellular Association of Nanoparticles Made by Polymerization‐Induced Self‐Assembly

PublicationsBy Gwen FewellJuly 25, 2018

Authors: Song Yang Khor, Mai N. Vu, Emily H. Pilkington, Angus P. R. Johnston, Michael R. Whittaker, John F. Quinn, Nghia P. Truong, Thomas P. Davis Source: onlinelibrary.wiley.com First published:…

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faseb journal

PKCδ Inhibition as a Novel Medical Countermeasure for Radiation‐Induced Vascular Damage

PublicationsBy Gwen FewellJune 13, 2018

Authors: Fariborz Soroush, Yuan Tang, Hasan M. Zaidi, Joel B. Sheffield, Laurie E. Kilpatrick, Mohammad F. Kiani Source: faseb.onlinelibrary.wiley.com First published: 13 June 2018 Synopsis: In the event of a…

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cancer letters journal

Rational Design and Development of a Peptide Inhibitor for the PD-1/ PD-L1 Interaction

PublicationsBy Gwen FewellApril 22, 2018

Authors: Rebecca J. Boohaker, Vijaya Sambandam, Isaac Segura, James Miller, Mark Suto, Bo Xu Source: journals.elsevier.com Received February 10, 2018. Received in revised form April 13, 2018. Accepted April 22,…

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scientific reports journal

A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy

PublicationsBy Gwen FewellFebruary 16, 2018

Authors: Shantanu Pradhan, Ashley M. Smith, Charles J. Garson, Iman Hassani, Wen J. Seeto, Kapil Pant, Robert D. Arnold, Balabhaskar Prabhakarpandian & Elizabeth A. Lipke Source: nature.com Scientific Reports volume…

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bioengineering translational medicine

Microfluidic Co-Culture Devices to Assess Penetration of Nanoparticles into Cancer Cell Mass

PublicationsBy Gwen FewellSeptember 26, 2017

Authors: Maria Jarvis, Michael Arnold, Jenna Ott, Kapil Pant, Balabhaskar Prabhakarpandian, Samir Mitragotri Source: pubmed.ncbi.nlm.nih.gov Bioeng Transl Med. 2017 Sep 26;2(3):268-277. doi: 10.1002/btm2.10079. eCollection 2017 Sep. Synopsis: In vitro and…

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plos one

Murine Glomerular Transcriptome Links Endothelial Cell-Specific Molecule-1 Deficiency with Susceptibility to Diabetic Nephropathy

PublicationsBy Gwen FewellSeptember 21, 2017

Authors: Xiaoyi Zheng, Fariborz Soroush, Jin Long, Evan T. Hall, Puneeth K. Adishesha, Sanchita Bhattacharya, Mohammad F. Kiani, Vivek Bhalla Source: ncbi.nlm.nih.gov Received: April 18, 2017. Accepted: September 8, 2017.…

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A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems

PublicationsBy Gwen FewellAugust 24, 2017

Authors: Yuan Tang, Fariborz Soroush, Joel B. Sheffield, Bin Wang, Balabhaskar Prabhakarpandian & Mohammad F. Kiani Source: nature.com Scientific Reports volume 7, Article number: 9359 (2017) Synopsis: Real-time monitoring of…

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oncotarget journal

Trastuzumab Distribution in an In-Vivo and In-Vitro Model of Brain Metastases of Breast Cancer

PublicationsBy Gwen FewellJuly 26, 2017

Authors: Tori B. Terrell-Hall, Mohamed Ismail Nounou, Fatema El-Amrawy, Jessica I.G. Griffith, and Paul R. Lockman Source: oncotarget.com Oncotarget. 2017; 8:83734-83744. Received: March 15, 2017. Accepted: July 03, 2017. Published: July 26,…

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Fluids-and-barriers

Permeability Across a Novel Microfluidic Blood-Tumor Barrier Model

PublicationsBy Gwen FewellJanuary 23, 2017

Authors: Tori B. Terrell-Hall, Amanda G. Ammer, Jessica I. G. Griffith, and Paul R. Lockman Source: ncbi.nlm.nih.gov Fluids Barriers CNS. 2017; 14: 3. Published online 2017 Jan 23. doi: 10.1186/s12987-017-0050-9…

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journal of Leukocyte Biology

A Novel Microfluidic Assay Reveals a Key Role for Protein Kinase C δ in Regulating Human Neutrophil-Endothelium Interaction

PublicationsBy Gwen FewellMay 17, 2016

Authors: Fariborz Soroush, Ting Zhang, Devon J King, Yuan Tang, Sudhir Deosarkar, Balabhaskar Prabhakarpandian, Laurie E Kilpatrick, Mohammad F Kiani Source: pubmed.ncbi.nlm.nih.gov J Leukoc Biol. 2016 Nov;100(5):1027-1035. doi: 10.1189/jlb.3MA0216-087R. Epub…

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plos one

A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip

PublicationsBy Gwen FewellNovember 10, 2015

Authors: Sudhir P. Deosarkar, Balabhaskar Prabhakarpandian, Bin Wang, Joel B. Sheffield, Barbara Krynska, Mohammad F. Kiani Source: journals.plos.org Published: November 10, 2015 Synopsis: Studies of neonatal neural pathologies and development…

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microvascular research journal

Adhesion Patterns in the Microvasculature are Dependent on Bifurcation Angle

PublicationsBy Gwen FewellMay 1, 2015

Authors: Giuseppina Lamberti, Fariborz Soroush, Ashley Smith, Mohammad F. Kiani, Balabhaskar Prabhakarpandian, Kapil Pant Source: sciencedirect.com Microvascular Research, Volume 99, May 2015, Pages 19-25 Synopsis: Particle adhesion in vivo is…

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Expanding Imaging Capabilities for Microfluidics: Applicability of Darkfield Internal Reflection Illumination (DIRI) to Observations in Microfluidics

PublicationsBy Gwen FewellMarch 6, 2015

Authors: Yoshihiro Kawano, Chino Otsuka, James Sanzo, Christopher Higgins, Tatsuo Nirei, Tobias Schilling, Takuji Ishikawa Source: journals.plos.org Published: March 6, 2015 Synopsis: Microfluidics is used increasingly for engineering and biomedical…

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journal of controlled release

Synthetic Tumor Networks for Screening Drug Delivery Systems

PublicationsBy Gwen FewellJanuary 17, 2015

Authors: Balabhaskar Prabhakarpandian, Ming-Che Shen, Joseph B. Nichols, Charles J. Garson, Ivy R. Mills, Majed M. Matar, Jason G. Fewell, Kapil Pant Source: Journal of Controlled Release Received August 28,…

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Bioinspired Microfluidic Assay for In Vitro Modeling of Leukocyte–Endothelium Interactions

PublicationsBy Gwen FewellJuly 28, 2014

Authors: Giuseppina Lamberti, Balabhaskar Prabhakarpandian, Charles Garson, Ashley Smith, Kapil Pant, Bin Wang, and Mohammad F. Kiani Source: pubs.acs.org Anal. Chem. 2014, 86, 16, 8344–8351. Publication Date: July 28, 2014…

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Generation of Shear Adhesion Map Using SynVivo Synthetic Microvascular Networks

PublicationsBy Gwen FewellMay 25, 2014

Authors: Ashley M. Smith, Balabhaskar Prabhakarpandian, Kapil Pant Source: jove.com doi: 10.3791/51025 Published: May 25, 2014 Synopsis: Cell/particle adhesion assays are critical to understanding the biochemical interactions involved in disease…

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microvascular research journal

Adhesive Interaction of Functionalized Particles and Endothelium in Idealized Microvascular Networks

PublicationsBy Gwen FewellSeptember 1, 2013

Authors: Giuseppin Lamberti, Yuan Tang, B. Prabhakarpandian, Yi Wang, Kapil Pant, Mohammad F. Kiani, Bin Wang Source: sciencedirect.com Microvascular Research Volume 89, September 2013 Synopsis: Leukocytes play a key role…

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pnas

Using Shape Effects to Target Antibody-Coated Nanoparticles to Lung and Brain Endothelium

PublicationsBy Gwen FewellJune 25, 2013

Authors: Poornima Kolhar, Aaron C. Anselmo, Vivek Gupta, Kapil Pant, Balabhaskar Prabhakarpandian, Erkki Ruoslahti, and Samir Mitragotri Source: pnas.org PNAS June 25, 2013 110 (26) 10753-10758 Synopsis: Vascular endothelium offers…

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lab on a chip

SyM-BBB: a Microfluidic Blood Brain Barrier Model

PublicationsBy Gwen FewellDecember 18, 2012

Authors: Balabhaskar Prabhakarpandian, Ming-Che Shen, Joseph B. Nichols, Ivy R. Mills, Marta Sidoryk-Wegrzynowicz, Michael Aschnerbcd and Kapil Panta Source: pubs.rsc.org Submitted Oct 31, 2012. Accepted Dec 18, 2012. First published…

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microvascular research journal

Microfluidic Devices for Modeling Cell–Cell and Particle–Cell Interactions in the Microvasculature

PublicationsBy Gwen FewellNovember 1, 2011

Authors: Balabhaskar Prabhakarpandian, Ming-Che Shen, Kapil Pant, Mohammad F. Kiani Source: sciencedirect.com Microvascular Research Volume 82, Issue 3, November 2011 Synopsis: Cell–fluid and cell–cell interactions are critical components of many…

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microcirculation journal

Bifurcations: Focal Points of Particle Adhesion in Microvascular Networks

PublicationsBy Gwen FewellMarch 19, 2011

Authors: Prabhakarpandian, Wang, Rea‐Ramsey, Sundaram, Kiani, and Pant Source: onlinelibrary.wiley.com First published: March 19, 2011 Synopsis: Particle adhesion in vivo is dependent on the microcirculation environment, which features unique anatomical (bifurcations,…

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microvascular research journal

Preferential Adhesion of Leukocytes Near Bifurcations is Endothelium Independent

PublicationsBy Gwen FewellDecember 1, 2010

Authors: Nazanin Tousi, Bin Wang, Kapil Pant, Mohammad F. Kiani, Balabhaskar Prabhakarpandian Source: sciencedirect.com Microvascular Research Volume 80, Issue 3, December 2010 Synopsis: Leukocyte–endothelial interactions play central roles in many…

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journal of controlled release

Flow and Adhesion of Drug Carriers in Blood Vessels Depend on their Shape: A Study Using Model Synthetic Microvascular Networks

PublicationsBy Gwen FewellSeptember 1, 2010

Authors: Nishit Doshi, Balabhaskar Prabhakarpandian, Angela Rea-Ramsey, Kapil Pant, Shivshankar Sundaram, Samir Mitragotri Source: sciencedirect.com Journal of Controlled Release Volume 146, Issue 2, 1 September 2010 Synopsis: Development of novel…

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biomedical microdevices journal

A Physiologically Realistic In-Vitro Model of Microvascular Networks

PublicationsBy Gwen FewellMay 19, 2009

Authors: Jenna M. Rosano, Nazanin Tousi, Robert C. Scott, Barbara Krynska, Victor Rizzo, Balabhaskar Prabhakarpandian, Kapil Pant, Shivshankar Sundaram & Mohammad F. Kiani Source: link.springer.com Biomedical Microdevices volume 11, Article…

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biomedical microdevices journal

Synthetic Microvascular Networks for Quantitative Analysis of Particle Adhesion

PublicationsBy Gwen FewellMarch 8, 2008

Authors: Balabhaskar Prabhakarpandian, Kapil Pant, Robert C. Scott, Christopher B. Patillo, Daniel Irimia, Mohammad F. Kiani & Shivshankar Sundaram Source: link.springer.com Biomedical Microdevices volume 10, pages585–595(2008) Synopsis: We have developed…

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