SynALI Lung-on-a-Chip
Morphologically realistic airway structure and environment allowing real-time visualization of cellular and barrier functionality
SynALI Idealized Linear Chip
SynALI™ lung-on-a-chip is a functionalized lung model composed of lung epithelial cells surrounded by a lung microvascular endothelium. The SynALI model maintains an Air Liquid Interface (ALI) across the airway cells, and allows for the formation of airway tubules, production and transportation of mucus and is supported and maintained by the surrounding endothelium. Cell morphology, airway structure, cell-cell interactions and functions of the airway (e.g., mucus transport, ciliary beating, therapeutic induced improvement) can be visualized and quantified in real-time in normal and diseased conditions. Dose drugs or chemicals in vapor or liquid phase.
Small Airway Lung Model
Co-culture with human bronchial epithelial cells (HBEC) and lung microvascular endothelial cells .
Alveolar Lung Model
Human microvascular lung endothelial cells and alveolar epithelial type I and II cells.
Lumenized Human Lung bronchial epithelial cells (HBEC)
Applications and Assays
Publications, Brochures, and Technical Manuals
Videos
Contract Research Services using SynALI models
Drug safety, toxicity, efficacy assays. Screen in liquid or vapor phase
SynALI Models Available
Human Small Airway Lung Model
- Monoculture using primary human lung bronchial epithelial or microvascular endothelial cells
- Co-Culture with human lung primary bronchial epithelial and microvascular endothelial cells
Human Alveolar Lung Model
- Monoculture using primary human lung alveolar epithelial or microvascular endothelial cells
- Co-Culture with human lung primary alveolar epithelial and microvascular endothelial cells
- Tri-Culture with human lung primary alveolar epithelial, endothelial and fibroblasts.
Assays Available
Toxicity assays
- Viability with Live Dead, apoptosis and ROS assays
- Acute inflammation with immune cell adhesion and migration assays, permeability and TEER
- Vascular injury
Biomarker analysis
- Immunocytochemistry, Cytokine profiing, QPCR
OMIC analysis
- Collect cells or effluents for downstream genomic, transcriptomic, proteomic or metabolomic analysis.
Therapeutic screening
Purchase SynALI Products and Instruments
Purchase starter kits, sets of chips, lung cells/cell lines, instrumentation and training workshops
SynALI Starter Kit: Select this for your first-time purchase. All the basic components required to run SynALI assays can be purchased in a kit format. The SynALI starter kit includes 12 chips, tubing, clamps, needles, syringes, pneumatic priming device (required for seeding cells).
Cells/Cell Lines: SynVivo offers human and animal lung cells and cell lines that have been tested and validated in the lung model.
SynALI Chip Options: Depending on your specific research applications you can select from Linear or Microvascular configurations.
Instrumentation: Syringe Pumps for cell seeding and maintaining flow based assays, stage top Incubator and inverted microscope for real time visualization and quantitation of your Lung assays
Training Workshops: SynVivo offers 2 and 4 day scientist-led training sessions. Gain hands on experience with our organ-on-a-chip technology.
Starter Kits - Select your chip model
Important Note: Starter kit does not include required consumables such as cells, media, and matrix. Other required equipment not included is syringe pumps, cell seeding pumps, incubators, and microscopes.
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Chip Model | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
 | 405001 | $2,100 |
SynALI Chip Model
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Chip Model | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
| 108011-SA3 | $375 |
Human Cells/Cell Lines
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CAT # | Product Name | Price | Qty | |
|---|---|---|---|---|
Syn-10HU-029 | $888 | |||
Syn-10HU-076 | $897 | |||
Syn-10HU-123 | $901 | |||
Syn-10HU-194 | $864 | |||
Syn-10HU-093 | $889 | |||
Syn-10HU-115 | $794 | |||
Syn-10HU-145 | $856 | |||
Syn-10HU-146 | $813 |
Training Workshops
Syringe Pumps - Instrumentation for Seeding Cells and Maintaining Flow Based Assays
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Image | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
 | 301004 | PHD Ultra 6/10 Multi Syringe Rack | $920 | ||
 | 301020 | Multichannel Programmable Syringe Pump – SynVivo NE 1200 | $2,100 | ||
 | 301002 | Pump 11 Elite Nanomite Infusion/Withdrawal Programmable Single Syringe | $3,790 | ||
 | 301003 | PHD Ultra Syringe Pump Programmable 2-Syringe Rack Standard Pressure | $5,651 |
Tokai Hit Stage Top Incubators
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Image | CAT# | Product Name | Contact Us |
|---|---|---|---|
 | 303015 | ||
| 303016 | ||
| 303017 |