In order to run flow based assays using our microfluidic chips you will need some basic lab equipment and instruments. We offer syringe pumps, pneumatic primer, cell impedance analyzer and stage top incubators to get you started using our platform.
Pneumatic Primer for Automated Priming of Chips
The pneumatic priming device is recommended for the automated priming of the co-culture SynVivo chips. This method is much simpler and more robust than the manual method which requires water immersion in a vacuum desiccator. Protocols for using SynVivo chips make use of this pneumatic priming device to impart a constant low pressure on the fluid to prime the microfluidic device.
Click to watch a video showing the pneumatic priming device in action.
Technical Manual – Setting up the Pneumatic Primer
SynVivo® Cell Impedance Analyzer
The SynVivo® Cell Impedance Analyzer is designed to measure changes in impedance (resistance) across cells cultured in SynVivo IMN2-Z devices. The SynVivo® Cell Impedance Analyzer provides real-time monitoring of cellular changes at a frequency of 500, 1,000, and 10,000 Hz.
Perfect for non-invasive and label-free monitoring of tight junction formation between cells, the system offers robust and easy protocols for error-free operations. It comes standard with power adapter and micro grabbers for use with SynVivo IMN2-Z devices.
SynBBB 3D Model TEER Configuration Technical Manual
Video- measuring resistance using the Synvivo Impedance Analyzer
Multichannel Programmable Syringe Pump – SynVivo NE 1200
SynVivo NE 1200- Catalog#: 301020
Designed for use with SynVivo’s microfluidic biochips, the NE-1200 pump runs consistently at low flow rates, has an easy to use keypad interface, is fully programmable from simple infusions to complex pumping programs and includes infusion and withdrawal capabilities. SynVivo NE-1200 offers a reliable syringe pump at an affordable cost.
- Holds 2, 4, 6, 8, 10 or 12 syringes of up to 3mL each
- Infusion rates from 0.454uL/hr (1mL syringe) to 153.2mL/hr
- Syringes are sold separately
Standard Infuse/Withdraw Pump 11 Elite Programmable
SynVivo Catalog#: 301001, Harvard Apparatus Catalog#: 70-4504, 70-4505
The Pump 11 Elite Series of syringe pumps expands its capabilities to satisfy your experimental requirements. These compact syringe pumps carry on the tradition as the premier workhorse infusion pump, offering unparalleled ease of use with a high-resolution touch screen with an intuitive icon interface. The Pump 11 Elite Series allows you to create, save, and run simple to complex methods without a PC.
These syringe pumps have a new mechanism that includes a tight gripping, a more secure syringe clamp for syringes ranging from 0.5µl to 60ml (single syringe), and 0.5µl to 10 ml (dual syringe). The Pump 11 Elite Series offers enhanced flow performance with high accuracy and smooth flow from 1.28 pl/min to 88.28 ml/min.
The Pump 11 Elite Series is available in Infusion Only or Infusion/Withdrawal Programmable Models with single or dual syringe racks. These pumps have advanced connectivity with a USB serial port for computer control, RS-485 (or optional RJ-ll) ports for daisy-chaining pumps, and Digital I/O for remote control.
Remote Infuse/Withdraw Pump 11 Elite Nanomite Programmable
SynVivo Catalog#: 301002, Harvard Apparatus Catalog#: 70-4507
The Pump 11 Elite Nanomite is a single syringe infusion/withdrawal programmable syringe pump with a flow rate range of 3.66 pl/min to 3.818 ml/min with 11 lbs of adjustable force across the entire flow rate range. It can accommodate syringes from 0.5 µl to 1 ml.
The Pump 11 Elite Nanomite Syringe Pump is very easy to use with an LCD color touch screen and icon interface. This pump allows you to create, save, and run simple to complex Methods without a PC. The Method profiles available on this pump are Constant Rate, Ramp, Gradient (binary), and Autofill. Delays can be set using the relative time clock.
The Message Area of the touch screen is used to display helpful instructions for the currently displayed screen. It is also used to display error or warning messages to indicate problem conditions in a Method or error conditions during pump operation. The Run Screen shows all of the pump parameters on one screen for easy review.
Standard Infuse/Withdraw Programmable PHD ULTRA™ Syringe Pumps
SynVivo Catalog#: 301003, Harvard Apparatus Catalog#: 70-3007
The PHD ULTRA™ is the solution for your most demanding fluidics applications. This pump represents the latest technology in syringe pumps and was developed utilizing the feedback of the world’s largest populations of syringe pump users. This pump is engineered to provide flow accuracy within 0.25% and reproducibility within 0.05%. Single or multi syringes from 0.5 µl to 140 ml pump at a range of 0.0001 µl/hr to 216 ml/min.
There are three major areas that make the PHD ULTRA™ the new standard for syringe pumps.
A. Superior mechanical drive mechanism and syringe holding mechanics to achieve high performance.
B. Integrated EZ PRO Software and user interface allow easy programming of methods from simple to complex, all without the use of a PC.
- Preprogrammed methods for simple to complex operations that allow you to be up and running with the push of a button
- LCD, high-resolution color touch screen for powerful functionality, yet easy to use
C. Multiple levels of versatility
- Configurations: push-pull, standard, remote, high pressure, multi racks
- Connectivity: RS-232 and USB for PC; RS-485 for the pump to pump daisy chain
PHD ULTRA™ 6×10 MultiRack
SynVivo Catalog#: 301004, Harvard Apparatus Catalog#: 70-3020
The PHD ULTRA is offered with a variety of syringe racks to meet your specific application. Multi-syringe racks provide multi-channel operation or serve as a large capacity reservoir.
The 6/10 multi-rack will hold up to 10 syringes from 0.5 µl to 20 ml and up to 6 syringes from 30 ml to 60 ml
PHD_ULTRA_Manual – see page 94 for assembly instructions.
Pump 33 DDS (Dual Drive System) Syringe Pump
SynVivo Catalog#: 301014, Harvard Apparatus Catalog#: 70-3333
The Harvard Apparatus Pump 33 DDS (Dual Drive System) is a leap forward in syringe pump capability. The Pump 33 DDS has two independent pumping channels controlled by an intuitive touch screen interface.
This multi-purpose syringe pump employs advanced syringe mechanisms that include a tight gripping, extremely secure syringe clamp that accommodates syringe sizes 0.5 µl to 60 ml. The Pump 33 DDS offers enhanced flow performance with high accuracy and smooth flow from 1.02 pl/min to 106 ml/min.
We have partnered with Tokai Hit to develop and sell stage top incubators specifically designed for use with SynVivo microfluidic chips and organ-on-chip models.
The Tokai Hit incubator offers precision temperature, humidity and CO2 control for long term cell culture on any microscope and optimal conditions for SynVivo’s microfluidic devices.
- Short and long term time-lapse imaging for periods greater than 2 weeks.
- Temperature, humidity and CO2 level maintenance to create an optimal cell culture environment.
- Internal humidifier reduces evaporation to eliminate undefined changes in the incubator.
- Custom adaptations for SynVivo’s microfluidic devices along with wellplates for general applications.
- Various control options depending on preferred gas type (premixed gas, 100% CO2 or CO2 & O2).
Chamber Unit Components
Top Heater
A transparent glass heater prevents condensation and visibility while heating the chamber from the upper surface.
Dish Attachment & Dish Fixing Lid
Enables various dish attachments including wellplates and SynVivo microfluidic chips with a user friendly magnetic holder.
Bath Unit
Bath heater directly heats distilled water in the bath unit to generate humidity in the chamber unit.
Access Ports
For media exchange and drug delivery tubing.
Lens Heater
Prevents the escape of heat between the specimen and the objective. Optimal for high magnification or oil/water immersion observation.
Incubator with Digital Controller for Heat and 2 Gas Mixer.
Tokai Hit Model #STXG-TIZWX-B20K
SynVivo Catalog #303016
Perfusion system including stage adaptor fitted to your microscope with a custom specimen holder for wellplates and one SynVivo microfluidic device under flow. Stage top environment with temperature controller, external sensors for manual calibration, water bath with humidification system, optical grade glass and a lens heater for immersion objective or short WD objective use. This system requires 100% CO2 and ambient air gas supply and mixes at a defined rate: 5-20%.
Incubator with Digital Controller for Premixed Tank
Tokai Hit Model #STXF-TIZWX-B20K
SynVivo Catalog #303015
Perfusion system including stage adaptor fitted to your microscope with a custom specimen holder for wellplates and one SynVivo microfluidic device under flow. Stage top environment with temperature controller, external sensors for manual calibration, water bath with humidification system, optical grade glass and a lens heater for immersion objective or short WD objective use. This system requires a 5% CO2 Source.
Incubator with Digital Controller for Heat and 3 Gas Mixer
Model: STXF-TIZWX-B20K-CO2O2
SynVivo Catalog #303017
Perfusion system including stage adaptor fitted to your microscope with a custom specimen holder for wellplates and one SynVivo microfluidic device under flow. Stage top environment with temperature controller, external sensors for manual calibration, water bath with humidification system, optical grade glass and a lens heater for immersion objective or short WD objective use. This system requires 100% CO2, 100% N2, 100% ambient air gas supply and mixes at a defined rate:O2:0.1-18%, CO2: 5-20%, N2: 0.1-18%.
Additional Items:
-Tokai Hit has customized a 4 chip holder for SynVivo devices. This slide holder and perfusion spacer can accommodate 4 SynVivo chips and flow based assays for long-term studies. The perfusion spacer adds 8 tubing ports to the chamber unit (Catalog #303018).
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CAT# | Product Name | Price |
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303018 | ||
303019 |